杭州浙大迪迅生物基因工程有限公司JACI：肠道微生物态与过敏、湿疹和哮喘的关系
发布日期：2019-04-15
原标题：肠道微生物态与过敏、湿疹和哮喘的关系:系统综述
延伸阅读
JACI
DOI: https://doi.org/10.1016/j.jaci.2018.09.025
The intestinal microbiota plays an important role in development of the immune system and regulation of immune responses. This review summarizes the association between the intestinal microbiota and the development of allergic sensitization, eczema, and asthma in neonates and children. Overall, a greater relative abundance of Bacteroidaceae, Clostridiaceae, and Enterobacteriaceae and a lower relative abundance of Bifidobacteriaceae and Lactobacillaceae is associated with the development of allergic sensitization, eczema, or asthma. Reduced bacterial diversity can be associated with the development of allergic disease. The association between the composition of the intestinal microbiota and the development of allergic disease or asthma is less consistent in older children than in neonates, suggesting that early-life microbial exposure plays a more important role. Inconsistencies in the results reported from different studies might partly be explained by heterogeneity in design, study populations, diagnostic criteria, microbiota analysis methods, and reporting on different taxonomic levels. Larger studies that better account for antenatal and postnatal factors will further help determine specific microbial intestinal signatures associated with increased risk of allergy and asthma. This will enable the early identification of infants at high risk and facilitate novel strategies and interventions to prevent and treat these conditions, including modifying the intestinal microbiota early in life.
All Authors:
Petra Zimmermann Nicole Messina William W. Mohn B. Brett Finlay Nigel Curtis
——浙大迪迅 译
肠道微生物群在免疫系统发育和免疫反应调控中起着重要作用。本文综述了新生儿和儿童肠道微生物群与过敏、湿疹和哮喘的关系。总的来说，杆菌科、梭菌科和肠杆菌科相对丰度较高，双歧杆菌科和乳酸菌科相对丰度较低，与过敏、湿疹或哮喘的发生有关。细菌多样性的减少可能与变应性疾病的发生有关。与新生儿相比，年龄较大的儿童肠道微生物群的组成与过敏性疾病或哮喘的发展之间的关系不太一致，这表明早期生活中微生物的接触扮演着更重要的角色。不同研究报告的结果不一致，部分原因可能是设计、研究群体、诊断标准、微生物群分析方法和不同分类水平的报告的异质性。更大规模的研究能更好地解释产前和产后因素，这将有助于进一步确定与过敏和哮喘风险增加相关的特定肠道微生物特征。这将使我们能早期识别高危婴儿，并促进预防和治疗这些疾病的新策略和干预措施的形成，包括在生命早期修改肠道微生物群。延伸阅读
JACI
[IF:13.1]
Association between the intestinal microbiota and allergic sensitization, eczema, and asthma: A systematic reviewDOI: https://doi.org/10.1016/j.jaci.2018.09.025
The intestinal microbiota plays an important role in development of the immune system and regulation of immune responses. This review summarizes the association between the intestinal microbiota and the development of allergic sensitization, eczema, and asthma in neonates and children. Overall, a greater relative abundance of Bacteroidaceae, Clostridiaceae, and Enterobacteriaceae and a lower relative abundance of Bifidobacteriaceae and Lactobacillaceae is associated with the development of allergic sensitization, eczema, or asthma. Reduced bacterial diversity can be associated with the development of allergic disease. The association between the composition of the intestinal microbiota and the development of allergic disease or asthma is less consistent in older children than in neonates, suggesting that early-life microbial exposure plays a more important role. Inconsistencies in the results reported from different studies might partly be explained by heterogeneity in design, study populations, diagnostic criteria, microbiota analysis methods, and reporting on different taxonomic levels. Larger studies that better account for antenatal and postnatal factors will further help determine specific microbial intestinal signatures associated with increased risk of allergy and asthma. This will enable the early identification of infants at high risk and facilitate novel strategies and interventions to prevent and treat these conditions, including modifying the intestinal microbiota early in life.
All Authors:
Petra Zimmermann Nicole Messina William W. Mohn B. Brett Finlay Nigel Curtis
2019-4-7 Review
创建过敏性疾病的科研、科普知识交流平台，为过敏患者提供专业诊断、治疗、预防的共享平台。
