杭州浙大迪迅生物基因工程有限公司JACI：哮喘的微生物组学研究
发布日期：2018-11-13
原标题：哮喘的微生物组学
——来自浙大迪迅
最近开发的敏感、特异、非培养方法的用于识别微生物的工具的应用正在改变微生物生态学的概念，包括与我们自身以及与健康和疾病状态相关的大量复杂微生物种群之间的关系。尽管大多数最初的工作集中于胃肠道微生物群落和胃肠疾病的关系,但目前兴趣已经扩大到包括研究哮喘及其表型与气道微生物的关系，胃肠道微生物之间的关系,免疫功能的开发、过敏和哮喘倾向的研究。在此，我们提供了关于哮喘患者和健康受试者之间气道微生物组差异研究，以及环境微生物组、肠道微生物组、免疫功能和哮喘进展之间的关系的研究。此外，我们提供了有关这些发现建议如何建立涉及直接操作肠道和气道微生物组来治疗和预防过敏性哮喘的广泛的基本原理。
延伸阅读
JACI
https://doi.org/10.1016/j.jaci.2014.11.011
Abstract:
The application of recently developed sensitive, specific, culture-independent tools for identification of microbes is transforming concepts of microbial ecology, including concepts of the relationships between the vast complex populations of microbes associated with ourselves and with states of health and disease. Although most work initially focused on the community of microbes (microbiome) in the gastrointestinal tract and its relationship to gastrointestinal disease, interest has expanded to include study of the relationships of the airway microbiome to asthma and its phenotypes and to the relationships between the gastrointestinal microbiome, development of immune function, and predisposition to allergic sensitization and asthma. Here we provide our perspective on the findings of studies of differences in the airway microbiome between asthmatic patients and healthy subjects and of studies of relationships between environmental microbiota, gut microbiota, immune function, and asthma development. In addition, we provide our perspective on how these findings suggest the broad outline of a rationale for approaches involving directed manipulation of the gut and airway microbiome for the treatment and prevention of allergic asthma.
First Author:
Yvonne J.Huang
Correspondence:
MDaHomer A.Boushey
All Authors:
——来自浙大迪迅
最近开发的敏感、特异、非培养方法的用于识别微生物的工具的应用正在改变微生物生态学的概念，包括与我们自身以及与健康和疾病状态相关的大量复杂微生物种群之间的关系。尽管大多数最初的工作集中于胃肠道微生物群落和胃肠疾病的关系,但目前兴趣已经扩大到包括研究哮喘及其表型与气道微生物的关系，胃肠道微生物之间的关系,免疫功能的开发、过敏和哮喘倾向的研究。在此，我们提供了关于哮喘患者和健康受试者之间气道微生物组差异研究，以及环境微生物组、肠道微生物组、免疫功能和哮喘进展之间的关系的研究。此外，我们提供了有关这些发现建议如何建立涉及直接操作肠道和气道微生物组来治疗和预防过敏性哮喘的广泛的基本原理。
延伸阅读
JACI
[IF:13.1]
The microbiome in asthmahttps://doi.org/10.1016/j.jaci.2014.11.011
Abstract:
The application of recently developed sensitive, specific, culture-independent tools for identification of microbes is transforming concepts of microbial ecology, including concepts of the relationships between the vast complex populations of microbes associated with ourselves and with states of health and disease. Although most work initially focused on the community of microbes (microbiome) in the gastrointestinal tract and its relationship to gastrointestinal disease, interest has expanded to include study of the relationships of the airway microbiome to asthma and its phenotypes and to the relationships between the gastrointestinal microbiome, development of immune function, and predisposition to allergic sensitization and asthma. Here we provide our perspective on the findings of studies of differences in the airway microbiome between asthmatic patients and healthy subjects and of studies of relationships between environmental microbiota, gut microbiota, immune function, and asthma development. In addition, we provide our perspective on how these findings suggest the broad outline of a rationale for approaches involving directed manipulation of the gut and airway microbiome for the treatment and prevention of allergic asthma.
First Author:
Yvonne J.Huang
Correspondence:
MDaHomer A.Boushey
All Authors:
2018-11-5 Review
创建过敏性疾病的科研、科普知识交流平台，为过敏患者提供专业诊断、治疗、预防的共享平台。
