杭州浙大迪迅生物基因工程有限公司Pain Ther：食物特异性 IgG4 抗体引导的排除饮食可改善慢性疼痛患者的状况
发布日期：2023-03-03
原标题：食物特异性 IgG4 抗体引导的排除饮食可改善慢性疼痛患者的状况
方法: 在患有慢性疼痛的男性和女性门诊患者中测定IgG4水平（采用快速试验和酶联免疫吸附试验（ELISA））。要求所有受试者在4周内排除血清中IgG4抗体水平较高的所有食物。在个性化排除饮食期之前（随访1）和之后（随访2）进行疼痛和生活质量问卷调查。采用视觉模拟量表(VAS)、意大利疼痛问卷(QUID)和马戈利斯(MA)问卷测定疼痛强度、疼痛特征和疼痛程度，采用健康简表调查(SF-36)和情绪状态量表(POMS)检测生活质量和情绪状态。对所有受试者的营养状况进行了评估。受试者组为育龄妇女（绝经前）、绝经至少1年的妇女和男性。
结果：54名患有慢性疼痛的受试者(12名神经性疼痛， 14名弥漫性疼痛，11名头痛， 17名腰痛)完成了两次随访和1个月的排除饮食。在第1次随访中，47名（87%）受试者对至少一种食物含有中/高水平的IgG4抗体。IgG4水平最高的食物是蛋类、乳制品、谷物和干果。在第2次随访中，IgG4水平降低、升高或不变均有呈现。在所有组中，4周的排除饮食导致所有疼痛指标显著降低，生活质量参数改善。特别是在第2次随访时， VAS评分下降了50%以上。
结论：基于IgG4抗体水平的食物消除饮食可有效减轻慢性疼痛患者的疼痛并改善其生活质量。
延伸阅读
Pain Ther
DOI: org/10.1007/s40122-022-00391-z
Abstract:
Introduction: Chronic pain is related to gastrointestinal (GI) functions because food components affect inflammation and pain through their action on the GI immune and/or neural system and because many analgesics interact with the gut to alter its structure and function. Immunoglobulin G4 (IgG4) are food-specific antibodies resulting from exposure of the gut immune system to nutrients. High IgG4 levels have been found to be associated with inflammation.
Methods: IgG4 were determined (both with the rapid test and enzyme-linked immunosorbent assay, ELISA) in men and women outpatients with chronic pain. All subjects were asked to exclude for 4 weeks all foods to which they had high blood levels of IgG4 antibodies. Pain and quality of life questionnaires were administered before (visit 1) and after (visit 2) the personalized exclusion diet period. Visual analogue scale (VAS), Italian Pain Questionnaire (QUID) and Margolis (MA) questionnaires were administered to determine pain intensity, pain features and pain extent, while Short Form Health Survey (SF-36) and Profile of Mood States (POMS) were used to test the quality of life and mood state. The nutritional status was evaluated in all subjects. Subject groups were women of reproductive age (pre-MW), women in menopause for at least 1 year (MW) and men.
Results: Fifty-four subjects with chronic pain(n = 12 neuropathic, n = 14 diffuse pain, n = 11 headache, n = 17 low back pain) completed the two visits and the 1-month exclusion diet. Atvisit 1, 47 (87%) subjects showed medium/high levels of IgG4 to at least one food. The foods showing the highest IgG4 values were eggs, dairy products, cereals and dried fruit. At visit 2, IgG4 levels were decreased, increased or unchanged. In all groups, the 4-week exclusion diet resulted in a significant reduction in all pain measures and an improvement of quality of life parameters. In particular, at visit 2, the VAS score determined in the morning decreased by more than 50%.
Conclusions: A food elimination diet based on IgG4 antibody levels may be effective in reducing pain and improving quality of life in patients with chronic pain.
First Author:
Ilenia Casini
Correspondence:
Department of Medicine, Surgery and Neuroscience,University of Siena, Via Aldo Moro, 2, 53100 Siena,Italy
2023-03-03 Article
——浙大迪迅译
序言：慢性疼痛与胃肠道（GI）功能有关，因为食物成分通过对胃肠道免疫和/或神经系统的作用来影响炎症和疼痛，而且许多镇痛药与肠道相互作用，改变其结构和功能。免疫球蛋白G4 (IgG4)是肠道免疫系统暴露于营养物质而产生的食物特异性抗体。目前已发现高IgG4水平与炎症有关。方法: 在患有慢性疼痛的男性和女性门诊患者中测定IgG4水平（采用快速试验和酶联免疫吸附试验（ELISA））。要求所有受试者在4周内排除血清中IgG4抗体水平较高的所有食物。在个性化排除饮食期之前（随访1）和之后（随访2）进行疼痛和生活质量问卷调查。采用视觉模拟量表(VAS)、意大利疼痛问卷(QUID)和马戈利斯(MA)问卷测定疼痛强度、疼痛特征和疼痛程度，采用健康简表调查(SF-36)和情绪状态量表(POMS)检测生活质量和情绪状态。对所有受试者的营养状况进行了评估。受试者组为育龄妇女（绝经前）、绝经至少1年的妇女和男性。
结果：54名患有慢性疼痛的受试者(12名神经性疼痛， 14名弥漫性疼痛，11名头痛， 17名腰痛)完成了两次随访和1个月的排除饮食。在第1次随访中，47名（87%）受试者对至少一种食物含有中/高水平的IgG4抗体。IgG4水平最高的食物是蛋类、乳制品、谷物和干果。在第2次随访中，IgG4水平降低、升高或不变均有呈现。在所有组中，4周的排除饮食导致所有疼痛指标显著降低，生活质量参数改善。特别是在第2次随访时， VAS评分下降了50%以上。
结论：基于IgG4抗体水平的食物消除饮食可有效减轻慢性疼痛患者的疼痛并改善其生活质量。
延伸阅读
Pain Ther
[IF：3.960]
Food-Specific IgG4 Antibody-Guided Exclusion Diet Improves Conditions of Patients with Chronic PainDOI: org/10.1007/s40122-022-00391-z
Abstract:
Introduction: Chronic pain is related to gastrointestinal (GI) functions because food components affect inflammation and pain through their action on the GI immune and/or neural system and because many analgesics interact with the gut to alter its structure and function. Immunoglobulin G4 (IgG4) are food-specific antibodies resulting from exposure of the gut immune system to nutrients. High IgG4 levels have been found to be associated with inflammation.
Methods: IgG4 were determined (both with the rapid test and enzyme-linked immunosorbent assay, ELISA) in men and women outpatients with chronic pain. All subjects were asked to exclude for 4 weeks all foods to which they had high blood levels of IgG4 antibodies. Pain and quality of life questionnaires were administered before (visit 1) and after (visit 2) the personalized exclusion diet period. Visual analogue scale (VAS), Italian Pain Questionnaire (QUID) and Margolis (MA) questionnaires were administered to determine pain intensity, pain features and pain extent, while Short Form Health Survey (SF-36) and Profile of Mood States (POMS) were used to test the quality of life and mood state. The nutritional status was evaluated in all subjects. Subject groups were women of reproductive age (pre-MW), women in menopause for at least 1 year (MW) and men.
Results: Fifty-four subjects with chronic pain(n = 12 neuropathic, n = 14 diffuse pain, n = 11 headache, n = 17 low back pain) completed the two visits and the 1-month exclusion diet. Atvisit 1, 47 (87%) subjects showed medium/high levels of IgG4 to at least one food. The foods showing the highest IgG4 values were eggs, dairy products, cereals and dried fruit. At visit 2, IgG4 levels were decreased, increased or unchanged. In all groups, the 4-week exclusion diet resulted in a significant reduction in all pain measures and an improvement of quality of life parameters. In particular, at visit 2, the VAS score determined in the morning decreased by more than 50%.
Conclusions: A food elimination diet based on IgG4 antibody levels may be effective in reducing pain and improving quality of life in patients with chronic pain.
First Author:
Ilenia Casini
Correspondence:
Department of Medicine, Surgery and Neuroscience,University of Siena, Via Aldo Moro, 2, 53100 Siena,Italy
2023-03-03 Article
