杭州浙大迪迅生物基因工程有限公司Allergy：家禽接触与农村儿童哮喘的环境保护
发布日期：2022-12-16
背景：哮喘是儿童期最常见的慢性疾病之一，在过去几十年中，其发病率一直在增加。最一致的流行病学调查结果显示，生活在农业或农村环境中的儿童免受哮喘和过敏的发展，但中国农村地区的保护因素尚不清楚。
方法：对17587名5至8岁儿童进行了基于社区的横断面流行病学研究，3435人来自香港（城市），14152人来自从化（中国南方农村）。哮喘和过敏症状以及环境暴露通过使用标准化和经验证的问卷来确定。
结果：从化农村地区当前喘息的患病率显著低于香港城市地区（1.7%对7.7%，p < 0.001)。与城市儿童相比，农村儿童的哮喘发病率也较低（2.5%对5.3%，p < 0.001)。在调整混杂因素后，暴露于农业（调整后的比值比0.74，95%置信区间：0.56–0.97）和家禽（0.75，0.59–0.96）是与农村地区哮喘保护效果相关的最重要因素。进一步的倾向评分调整分析表明，生活在农村环境中的这种保护主要归因于家禽接触。
结论：我们证实，与城市同龄人相比，农村儿童哮喘和特应性疾病的患病率明显更低。在农村地区，接触家禽和农业是与哮喘防护相关的最重要因素。
原始出处
Allergy
DOI: 10.1111/all.15365
Abstract:
Background: Asthma is one of the most common chronic diseases in childhood, and the prevalence has been increasing over the past few decades. One of the most consistent epidemiological findings is that children living in a farming or rural environment are protected from development of asthma and allergies, but the protective factors in rural China are not clear.
Methods: A community-based, cross-sectional epidemiological study was performed in a total of 17,587 children aged 5–8 years, 3435 from Hong Kong (urban) and 14,152 from Conghua (rural county in southern China). Asthma and allergic symptoms as well as environmental exposures were ascertained by using a standardized and validated questionnaire.
Results: The prevalence of current wheeze was significantly lower in rural Conghua than that of urban Hong Kong (1.7% vs. 7.7%, p < 0.001). A lower rate of asthma ever was also reported in rural children compared with their urban counterparts (2.5% vs. 5.3%, p < 0.001). After adjusting for confounding factors, exposure to agricultural farming (adjusted odds ratio 0.74, 95% confidence interval: 0.56–0.97) and poultry (0.75, 0.59–0.96) were the most important factors associated with the asthma-protective effect in the rural area. Further propensity score-adjusted analysis indicated that such protection conferred by living in the rural environment was mainly attributable to poultry exposure.
Conclusion: We confirmed that the prevalence of asthma and atopic disorders was significantly lower in rural children when compared with their urban peers. Exposure to poultry and agricultural farming are the most important factors associated with asthma protection in the rural area.
First Author:
Yuhan Xing
Correspondence:
Gary W.K. Wong, Department of Paediatrics, Prince of Wales Hospital, Faculty of Medicine, Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China.
2022-12-16 Article
方法：对17587名5至8岁儿童进行了基于社区的横断面流行病学研究，3435人来自香港（城市），14152人来自从化（中国南方农村）。哮喘和过敏症状以及环境暴露通过使用标准化和经验证的问卷来确定。
结果：从化农村地区当前喘息的患病率显著低于香港城市地区（1.7%对7.7%，p < 0.001)。与城市儿童相比，农村儿童的哮喘发病率也较低（2.5%对5.3%，p < 0.001)。在调整混杂因素后，暴露于农业（调整后的比值比0.74，95%置信区间：0.56–0.97）和家禽（0.75，0.59–0.96）是与农村地区哮喘保护效果相关的最重要因素。进一步的倾向评分调整分析表明，生活在农村环境中的这种保护主要归因于家禽接触。
结论：我们证实，与城市同龄人相比，农村儿童哮喘和特应性疾病的患病率明显更低。在农村地区，接触家禽和农业是与哮喘防护相关的最重要因素。
原始出处
Allergy
[IF：13.146]
Poultry exposure and environmental protection against asthma in rural childrenDOI: 10.1111/all.15365
Abstract:
Background: Asthma is one of the most common chronic diseases in childhood, and the prevalence has been increasing over the past few decades. One of the most consistent epidemiological findings is that children living in a farming or rural environment are protected from development of asthma and allergies, but the protective factors in rural China are not clear.
Methods: A community-based, cross-sectional epidemiological study was performed in a total of 17,587 children aged 5–8 years, 3435 from Hong Kong (urban) and 14,152 from Conghua (rural county in southern China). Asthma and allergic symptoms as well as environmental exposures were ascertained by using a standardized and validated questionnaire.
Results: The prevalence of current wheeze was significantly lower in rural Conghua than that of urban Hong Kong (1.7% vs. 7.7%, p < 0.001). A lower rate of asthma ever was also reported in rural children compared with their urban counterparts (2.5% vs. 5.3%, p < 0.001). After adjusting for confounding factors, exposure to agricultural farming (adjusted odds ratio 0.74, 95% confidence interval: 0.56–0.97) and poultry (0.75, 0.59–0.96) were the most important factors associated with the asthma-protective effect in the rural area. Further propensity score-adjusted analysis indicated that such protection conferred by living in the rural environment was mainly attributable to poultry exposure.
Conclusion: We confirmed that the prevalence of asthma and atopic disorders was significantly lower in rural children when compared with their urban peers. Exposure to poultry and agricultural farming are the most important factors associated with asthma protection in the rural area.
First Author:
Yuhan Xing
Correspondence:
Gary W.K. Wong, Department of Paediatrics, Prince of Wales Hospital, Faculty of Medicine, Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China.
2022-12-16 Article
