① 猫毛敏感的分子模式因人而异，它们与哮喘患者炎症的关系还没有得到广泛的研究；② 纳入哮喘病人266人（10-35岁），其IgE对猫毛、狗毛和马毛敏感（ImmunoCAP），分析IgE对猫毛过敏原成分Fel d1(分泌球蛋白)、Fel d2(血清白蛋白)、Fel d4、Fel d7(脂蛋白)的影响；③ IgE对Fel d2的水平与FeNO (p=0.012)和总IgE (p<0.001)有相关；④IgE对于Fel d 1和猫毛提取的炎症标记物无任何关联(p = 0.23−0.51)；⑤ 青年哮喘患者血清中IgE对脂蛋白(Fel d 4)和血清白蛋白(Fel d 2)的水平与2型生物标志物和总IgE含量相关。
Clinical & Experimental Allergy
Sensitisation to minor cat allergen components is associated with type-2 biomarkers in young asthmatics
Background: Cat allergy is a major trigger of asthma worldwide. Molecular patterns of cat sensitisationvary between individuals, but their relationship to inflammation in asthmatics has not beenextensively studied.
Methods: Patients with asthma (age 10−35 years; n=266) and IgE sensitisation to cat, dog or horse extract (ImmunoCAP), were analysed for IgE to the cat allergen components Fel d 1 (secretoglobin), Fel d 2 (serum albumin), Fel d 4 and Fel d 7 (lipocalins). Independent associations between IgE-antibody concentrations, and fraction of exhaled nitric oxide (FeNO), blood eosinophil (B-Eos) count, and total IgE were analysed by multiple linear regression after adjustment for possible confounders.
Results: The level of IgE against Fel d 2 was independently related to FeNO (p=0.012) and total IgE (p<0.001), and IgE against Fel d 4 associated with Β-Eos count (p=0.009) and total IgE (p<0.001). IgE antibodies against Fel d 1 or cat extract did not independently relate to these inflammatory markers (p=0.23−0.51).
Conclusions: Levels of IgE to lipocalin (Fel d 4) and serum albumin (Fel d 2), but not to secretoglobin (Fel d 1) or cat extract, were independently associated with type-2 biomarkers and total IgE in young asthmatics.
Department of Women’s and Children’s Health, Uppsala University
Tsolakis N, Malinovschi A, Nordvall L, Mattsson L, Lidholm J, Pedroletti C, Janson C, Borres M.P, and Alving K