杭州浙大迪迅生物基因工程有限公司Allergy：接受食物过敏口服免疫治疗的8-12岁儿童的生活质量
发布日期：2020-11-26
原标题：接受食物过敏口服免疫治疗的8-12岁儿童的生活质量：儿童和父母的看法
方法：使用具有针对性的食物过敏生活质量问卷，对接受OIT的儿童（8-12岁）及其父母分别展开调查，时间节点设置为“开始进行牛奶、鸡蛋、花生、芝麻或坚果的OIT时”、“最后一次给药结束时”和“6个月后的随访时”。未接受OIT的食物过敏儿童作为对照组。比较分析儿童与其父母在QOL评分上的差异。
结果：103名接受OIT治疗的儿童的调查问卷评分从OIT开始时的（中位数（IQR）；4.8，3.8-5.7）到给药结束时的（3.9，3-5.2），有明显的改善（P<0.001）。观察到在接受随访的56名儿童中表现出更显著的改善，从OIT开始时的5.0（3.7-5.8）到随访时的3.1（1.8-5.0）（P<0.001）。相比之下，对照组儿童患者的调查问卷评分在两个时间点从5.3（4.3-5.7）到4.8（3.6-6.0）有轻度的改善，但无显著性差异（P=0.13）。在观察期间，与对照组儿童患者的变化相比，OIT组从OIT开始到随访结束的调查问卷总评分有显著的改善（P= 0.015）。在OIT的所有阶段，父母的生活质量评分都比他们的孩子要好（开始4.0，3.2-5，P=0.004；结束给药2.9，1.9-4.7，P=0.04；随访2.2，1.6-3.6，P=0.003）。
结论：与对照组相比，接受OIT的食物过敏儿童的QOL评分显著改善。父母认为孩子生活质量改善的情况要优于孩子自身的看法。
延伸阅读
Allergy
DOI: 10.1111/all.14350
Abstract:
Background: Oral immunotherapy (OIT) for food allergy improves the quality of life (QOL) of children from parental perspective but little is known about the child perception.
Methods: The Food Allergy Quality of Life Questionnaire—Child Form (FAQLQ-CF) was administered to children aged 8-12 years, and the FAQLQ—Parent Form (FAQLQ-PF) was administered to their parents at the start of OIT for milk, egg, peanut, sesame, or tree nuts, at the end of up-dosing, and after 6 months of follow-up. Food-allergic children not undergoing OIT served as controls. Children QOL scores were compared to their parents.
Results: The total FAQLQ-CF score of 103 children undergoing OIT improved significantly from start of OIT (median (IQR); 4.8, 3.8-5.7) to end of up-dosing (3.9, 3-5.2) (P < .001). A greater improvement was noted in the 56 children who reached a followup visit, from 5.0 (3.7-5.8) at OIT start to 3.1 (1.8-5.0) on follow-up, (P < .001). In contrast, FAQLQ-CF scores of control patients improved mildly and nonsignificantly between the two time points from 5.3 (4.3-5.7) to 4.8 (3.6-6.0), (P = .13). The improvement in the total FAQLQ-CF scores from OIT start to follow-up was significantly greater compared to the change in control patients during observation (P = .015).
Parents reported better QOL scores compared to their children at all stages of OIT (start 4.0, 3.2-5, P = .004; end of up-dosing 2.9, 1.9-4.7, P = .04; follow-up 2.2, 1.6-3.6, P = .003).
Conclusion: QOL of food-allergic children undergoing OIT improves significantly compared to controls. Parents perceive QOL to be better than the perception of the children.
First Author:
Na'ama Epstein-Rigbi
Correspondence:
Na’ama Epstein-Rigbi, The Institute of Allergy, Asthma and Immunology, Shamir Medical Center (former Assaf Harofeh), Zerifin 71300, Israel.
All Authors:
Na'ama Epstein-Rigbi, Michael R. Goldberg, Michael B. Levy, Liat Nachshon, Arnon Elizur
2020-11-26 Article
创建过敏性疾病的科研、科普知识交流平台，为过敏患者提供专业诊断、治疗、预防的共享平台。
——浙大迪迅 译
背景：一般来说，父母都认为口服免疫疗法（OIT）可以改善食物过敏儿童的生活质量（QOL），但是儿童自身对该疗法的看法知之甚少。方法：使用具有针对性的食物过敏生活质量问卷，对接受OIT的儿童（8-12岁）及其父母分别展开调查，时间节点设置为“开始进行牛奶、鸡蛋、花生、芝麻或坚果的OIT时”、“最后一次给药结束时”和“6个月后的随访时”。未接受OIT的食物过敏儿童作为对照组。比较分析儿童与其父母在QOL评分上的差异。
结果：103名接受OIT治疗的儿童的调查问卷评分从OIT开始时的（中位数（IQR）；4.8，3.8-5.7）到给药结束时的（3.9，3-5.2），有明显的改善（P<0.001）。观察到在接受随访的56名儿童中表现出更显著的改善，从OIT开始时的5.0（3.7-5.8）到随访时的3.1（1.8-5.0）（P<0.001）。相比之下，对照组儿童患者的调查问卷评分在两个时间点从5.3（4.3-5.7）到4.8（3.6-6.0）有轻度的改善，但无显著性差异（P=0.13）。在观察期间，与对照组儿童患者的变化相比，OIT组从OIT开始到随访结束的调查问卷总评分有显著的改善（P= 0.015）。在OIT的所有阶段，父母的生活质量评分都比他们的孩子要好（开始4.0，3.2-5，P=0.004；结束给药2.9，1.9-4.7，P=0.04；随访2.2，1.6-3.6，P=0.003）。
结论：与对照组相比，接受OIT的食物过敏儿童的QOL评分显著改善。父母认为孩子生活质量改善的情况要优于孩子自身的看法。
延伸阅读
Allergy
[IF:6.771]
Quality of life of children aged 8-12 years undergoing food allergy oral immunotherapy: Child and parent perspectiveDOI: 10.1111/all.14350
Abstract:
Background: Oral immunotherapy (OIT) for food allergy improves the quality of life (QOL) of children from parental perspective but little is known about the child perception.
Methods: The Food Allergy Quality of Life Questionnaire—Child Form (FAQLQ-CF) was administered to children aged 8-12 years, and the FAQLQ—Parent Form (FAQLQ-PF) was administered to their parents at the start of OIT for milk, egg, peanut, sesame, or tree nuts, at the end of up-dosing, and after 6 months of follow-up. Food-allergic children not undergoing OIT served as controls. Children QOL scores were compared to their parents.
Results: The total FAQLQ-CF score of 103 children undergoing OIT improved significantly from start of OIT (median (IQR); 4.8, 3.8-5.7) to end of up-dosing (3.9, 3-5.2) (P < .001). A greater improvement was noted in the 56 children who reached a followup visit, from 5.0 (3.7-5.8) at OIT start to 3.1 (1.8-5.0) on follow-up, (P < .001). In contrast, FAQLQ-CF scores of control patients improved mildly and nonsignificantly between the two time points from 5.3 (4.3-5.7) to 4.8 (3.6-6.0), (P = .13). The improvement in the total FAQLQ-CF scores from OIT start to follow-up was significantly greater compared to the change in control patients during observation (P = .015).
Parents reported better QOL scores compared to their children at all stages of OIT (start 4.0, 3.2-5, P = .004; end of up-dosing 2.9, 1.9-4.7, P = .04; follow-up 2.2, 1.6-3.6, P = .003).
Conclusion: QOL of food-allergic children undergoing OIT improves significantly compared to controls. Parents perceive QOL to be better than the perception of the children.
First Author:
Na'ama Epstein-Rigbi
Correspondence:
Na’ama Epstein-Rigbi, The Institute of Allergy, Asthma and Immunology, Shamir Medical Center (former Assaf Harofeh), Zerifin 71300, Israel.
All Authors:
Na'ama Epstein-Rigbi, Michael R. Goldberg, Michael B. Levy, Liat Nachshon, Arnon Elizur
2020-11-26 Article
创建过敏性疾病的科研、科普知识交流平台，为过敏患者提供专业诊断、治疗、预防的共享平台。
