杭州浙大迪迅生物基因工程有限公司JACI：特应性皮炎病人的微生物组学
发布日期：2019-03-01
原标题：特应性皮炎病人的微生物组学
延伸阅读
JACI Volume 143, Issue 1, January 2019, Pages 26-35
[IF:13.1]
The microbiome in patients with atopic dermatitis
https://doi.org/10.1016/j.jaci.2018.11.015
As an interface with the environment, the skin is a complex ecosystem colonized by many microorganisms that coexist in an established balance. The cutaneous microbiome inhibits colonization with pathogens, such as Staphylococcus aureus, and is a crucial component for function of the epidermal barrier. Moreover, crosstalk between commensals and the immune system is now recognized because microorganisms can modulate both innate and adaptive immune responses. Host-commensal interactions also have an effect on the developing immune system in infants and, subsequently, the occurrence of diseases, such as asthma and atopic dermatitis (AD). Later in life, the cutaneous microbiome contributes to the development and course of skin disease. Accordingly, in patients with AD, a decrease in microbiome diversity correlates with disease severity and increased colonization with pathogenic bacteria, such as S aureus. Early clinical studies suggest that topical application of commensal organisms (eg, Staphylococcus hominis or Roseomonas mucosa) reduces AD severity, which supports an important role for commensals in decreasing S aureus colonization in patients with AD. Advancing knowledge of the cutaneous microbiome and its function in modulating the course of skin disorders, such as AD, might result in novel therapeutic strategies.
All Author:
Amy S.PallerMSc, MDaHeidi H.KongMD, MHScbPatrickSeedMD, PhDaShrutiNaikPhDcTiffany C.ScharschmidtMDdRichard L.GalloMD, PhDeThomasLugerMDfAlan D.IrvineMD, DScg
——浙大迪迅 译
作为与环境接触面，皮肤是人体一个复杂的生态系统，由许多微生物在一个既定的平衡中共存。皮肤微生物组抑制病原菌(如金黄色葡萄球菌)的定植，是表皮屏障功能的重要组成部分。此外，由于微生物可以调节先天免疫反应和适应性免疫反应，共体和免疫系统之间的相互作用也得到了承认。寄主与寄主之间的相互作用也会影响婴儿免疫系统的发育，进而影响哮喘和特应性皮炎(AD)等疾病的发生。在以后的生活中，皮肤微生物群参与了皮肤病的发展和过程。因此，在AD患者中，微生物组多样性的降低与疾病的严重程度和致病菌(如金黄色葡萄球菌)的定植增加有关。早期临床研究表明，局部应用共生菌(如人葡萄球菌或玫瑰单胞菌黏膜)可降低AD的严重程度，这支持了共生菌在降低AD患者金黄色葡萄球菌定植中的重要作用。进一步了解皮肤微生物群及其在调节AD等皮肤疾病过程中的作用，可能会产生新的治疗策略。
延伸阅读
JACI Volume 143, Issue 1, January 2019, Pages 26-35
[IF:13.1]
The microbiome in patients with atopic dermatitis
https://doi.org/10.1016/j.jaci.2018.11.015
As an interface with the environment, the skin is a complex ecosystem colonized by many microorganisms that coexist in an established balance. The cutaneous microbiome inhibits colonization with pathogens, such as Staphylococcus aureus, and is a crucial component for function of the epidermal barrier. Moreover, crosstalk between commensals and the immune system is now recognized because microorganisms can modulate both innate and adaptive immune responses. Host-commensal interactions also have an effect on the developing immune system in infants and, subsequently, the occurrence of diseases, such as asthma and atopic dermatitis (AD). Later in life, the cutaneous microbiome contributes to the development and course of skin disease. Accordingly, in patients with AD, a decrease in microbiome diversity correlates with disease severity and increased colonization with pathogenic bacteria, such as S aureus. Early clinical studies suggest that topical application of commensal organisms (eg, Staphylococcus hominis or Roseomonas mucosa) reduces AD severity, which supports an important role for commensals in decreasing S aureus colonization in patients with AD. Advancing knowledge of the cutaneous microbiome and its function in modulating the course of skin disorders, such as AD, might result in novel therapeutic strategies.
All Author:
Amy S.PallerMSc, MDaHeidi H.KongMD, MHScbPatrickSeedMD, PhDaShrutiNaikPhDcTiffany C.ScharschmidtMDdRichard L.GalloMD, PhDeThomasLugerMDfAlan D.IrvineMD, DScg
2019-1-17 review
创建过敏性疾病的科研、科普知识交流平台，为过敏患者提供专业诊断、治疗、预防的共享平台。
