杭州浙大迪迅生物基因工程有限公司JACI：免疫治疗期间IgE、IgG4应答的变化
发布日期：2019-01-17
原标题：免疫治疗期间对户尘螨的IgE、IgG4应答的改变
(sIgE)和IgG4 (sIgG4)的变化，并评价其临床疗效。②我们回顾性分析了51名5 - 16岁被诊断为变应性鼻炎和/或哮喘的户尘螨过敏儿童，这些儿童经过36个月的特异性免疫治疗。我们还收集了同期对照队列的50名服用常规药物治疗HDM过敏患者的数据。在研究组中，我们记录了基线时以及特异性免疫治疗6、12、24和36个月时的对HDM户尘螨全部过敏原 (Der p)、Der p1和Der p2 的sIgE和sIgG4的水平。③血清sIgE反应在SIT6个月后升高，但随后下降。在36个月时，抗p1和抗p2 sIgEs下降到基线以下。在SIT时，对Der p血清sIgG4的反应最大，其次是Der p1和Der p2。Der 1的sIgE/sIgG4比值的下降高于其他过敏原的最大降幅。与年龄较大的儿童相比，5 - 8岁儿童的sIgG4应答更为明显，尤其对Der p1和Der p2。④ HDM特异性免疫治疗早期刺激了对HDM过敏原sIgE和sIgG4应答。随着sIgE/sIgG4比值的逐渐下降，特别是针对Der p1的sIgE/sIgG4。年幼的孩子可能比年长的孩子表现出更快速的SIT反应。
延伸阅读
JACI：
DOI: https://doi.org/10.1016/j.jaci.2015.12.202 |
Abstract:
Background
Rationale
We investigated the changes in serum-specific IgE (sIgE) and IgG4 (sIgG4) against house dust mite (HDM) and its components Der p 1 and Der p 2 during specific immunotherapy (SIT), and evaluated the clinical efficacy thereof.
Methods
We retrospectively analyzed 51 HDM-sensitized children aged 5 to 16 years diagnosed with allergic rhinitis and/or asthma, following 36 months of SIT. We also collected data from a contemporary control cohort of 50 patients administered routine medications for HDM allergy. . In the test cases, we recorded the sIgE and sIgG4 levels against the whole allergen of HDM (Der p), Der p 1 and Der p 2 at baseline and at 6, 12, 24 and 36 months of SIT.
Results
The serum sIgE response increased up to 6 months of SIT, but subsequently declined. At 36 months, the anti-Der p 1 and anti-Der p 2 sIgEs plummeted below the baseline. During SIT, the increased serum sIgG4 response was the greatest against Der p, followed by Der p 1 and Der p 2. The decline in sIgE/sIgG4 ratio for Der 1 was higher than for the other allergensmaximum decline. Compared with older children, children aged 5 to 8 manifested a clearer sIgG4 response, especially against Der p 1 and Der p 2 versus Der p.
Conclusions
SIT for HDM stimulated an early sIgE and sIgG4 response against HDM allergens. with a progressive decline in the ratio of sIgE/sIgG4, especially against Der p 1. Younger children may manifest a more rapid response to SIT than older ones.
All Author:
Baoqing Sun, MHA, Zheng Peiya
——浙大迪迅 译
①研究特异性免疫治疗(SIT)期间对尘螨(HDM)及其组分Der p1和Der p2血清特异性IgE(sIgE)和IgG4 (sIgG4)的变化，并评价其临床疗效。②我们回顾性分析了51名5 - 16岁被诊断为变应性鼻炎和/或哮喘的户尘螨过敏儿童，这些儿童经过36个月的特异性免疫治疗。我们还收集了同期对照队列的50名服用常规药物治疗HDM过敏患者的数据。在研究组中，我们记录了基线时以及特异性免疫治疗6、12、24和36个月时的对HDM户尘螨全部过敏原 (Der p)、Der p1和Der p2 的sIgE和sIgG4的水平。③血清sIgE反应在SIT6个月后升高，但随后下降。在36个月时，抗p1和抗p2 sIgEs下降到基线以下。在SIT时，对Der p血清sIgG4的反应最大，其次是Der p1和Der p2。Der 1的sIgE/sIgG4比值的下降高于其他过敏原的最大降幅。与年龄较大的儿童相比，5 - 8岁儿童的sIgG4应答更为明显，尤其对Der p1和Der p2。④ HDM特异性免疫治疗早期刺激了对HDM过敏原sIgE和sIgG4应答。随着sIgE/sIgG4比值的逐渐下降，特别是针对Der p1的sIgE/sIgG4。年幼的孩子可能比年长的孩子表现出更快速的SIT反应。
延伸阅读
JACI：
[IF:13.1]
Altered Serum IgE and IgG4 Response to Dermatophagoides Pteronyssinus Allergens during Specific ImmunotherapyDOI: https://doi.org/10.1016/j.jaci.2015.12.202 |
Abstract:
Background
Rationale
We investigated the changes in serum-specific IgE (sIgE) and IgG4 (sIgG4) against house dust mite (HDM) and its components Der p 1 and Der p 2 during specific immunotherapy (SIT), and evaluated the clinical efficacy thereof.
Methods
We retrospectively analyzed 51 HDM-sensitized children aged 5 to 16 years diagnosed with allergic rhinitis and/or asthma, following 36 months of SIT. We also collected data from a contemporary control cohort of 50 patients administered routine medications for HDM allergy. . In the test cases, we recorded the sIgE and sIgG4 levels against the whole allergen of HDM (Der p), Der p 1 and Der p 2 at baseline and at 6, 12, 24 and 36 months of SIT.
Results
The serum sIgE response increased up to 6 months of SIT, but subsequently declined. At 36 months, the anti-Der p 1 and anti-Der p 2 sIgEs plummeted below the baseline. During SIT, the increased serum sIgG4 response was the greatest against Der p, followed by Der p 1 and Der p 2. The decline in sIgE/sIgG4 ratio for Der 1 was higher than for the other allergensmaximum decline. Compared with older children, children aged 5 to 8 manifested a clearer sIgG4 response, especially against Der p 1 and Der p 2 versus Der p.
Conclusions
SIT for HDM stimulated an early sIgE and sIgG4 response against HDM allergens. with a progressive decline in the ratio of sIgE/sIgG4, especially against Der p 1. Younger children may manifest a more rapid response to SIT than older ones.
All Author:
Baoqing Sun, MHA, Zheng Peiya
2018-12-27 Article
创建过敏性疾病的科研、科普知识交流平台，为过敏患者提供专业诊断、治疗、预防的共享平台。
