杭州浙大迪迅生物基因工程有限公司Clin Exp Allergy: 树花粉暴露与儿童肺功能下有关
发布日期：2020-10-30
原标题：树花粉暴露与儿童肺功能下降有关
方法：本研究对一组居住在澳大利亚悉尼的高危儿童在8岁和14岁时进行肺活量测定和呼出一氧化氮（FeNO）测定。以肺功能测定当天及之前3天的环境花粉浓度作为暴露测量。住宅区的绿色度是从卫星图像中提取出来的。我们模拟了6种花粉类型与肺功能和FeNO的关系。我们也评估了住宅绿化的改善效果。
结果：测量前1天和前3天空气中的木麻黄、柏树和松树花粉与8岁儿童肺功能降低有关。花粉暴露与FEV1和FVC降低有关，但FEV1/FVC比值不受影响。
结论：空气中的柏树、木麻黄、松树花粉在某些地区可能不利于儿童肺功能。
延伸阅读
Clinical & Experimental Allergy
DOI: 10.1111/cea.13711
Abstract:
Background: Allergic disease is a recognized global epidemic and a significant cause of ill health and poor quality of life. The prevalence of pollen allergy is high throughout the world, and pollen exposure itself plays a role in emergency department presentations and hospitalizations for asthma. Lung function and airway inflammation are important measures of asthma activity and control.
Methods: A cohort of high-risk children living in Sydney, Australia had spirometry and fractional exhaled nitric oxide (FeNO) measured at 8 and 14 years of age. Ambient pollen concentration on the day of lung function measurement and up to three days prior was used as the exposure measure. Residential greenness was derived from satellite imagery. We modelled the association between six pollen types and lung function and FeNO. We also assessed modifying effects of residential greenness.
Results: Casuarina, cypress and Pinus pollen in the air the day before measurement and 3 days prior respectively, were associated with reduced lung function in 8-yearolds. The pollen exposures were associated with decreases in FEV1 and FVC; however, the FEV1/FVC ratio was not affected. Effect modification by greenness was not observed due to loss of power.
Conclusions: Airborne tree pollen of cypress, Casuarina and Pinus and not grass in some regions may be detrimental to childhood lung function.
First Author:
Katrina A Lambert
Correspondence:
Bircan Erbas, School of Public Health, La Trobe University, Rm 129, Health Sciences 1, Bundoora, Vic. 3086, Australia.
All Authors:
Katrina A Lambert, Constance Katelaris, Pamela Burton, Christine Cowie, Caroline Lodge, Frances L Garden, Luke A Prendergast, Brett G Toelle, Bircan Erbas
2020-10-30 Article
创建过敏性疾病的科研、科普知识交流平台，为过敏患者提供专业诊断、治疗、预防的共享平台。
——浙大迪迅 译
背景：过敏性疾病是一种公认的全球性流行病，是导致健康状况差和生活质量低下的重要原因。花粉过敏的流行率在世界各地都很高，花粉暴露在哮喘急诊和住院治疗中扮演着重要角色。肺功能和气道炎症是哮喘发作和控制的重要指标。方法：本研究对一组居住在澳大利亚悉尼的高危儿童在8岁和14岁时进行肺活量测定和呼出一氧化氮（FeNO）测定。以肺功能测定当天及之前3天的环境花粉浓度作为暴露测量。住宅区的绿色度是从卫星图像中提取出来的。我们模拟了6种花粉类型与肺功能和FeNO的关系。我们也评估了住宅绿化的改善效果。
结果：测量前1天和前3天空气中的木麻黄、柏树和松树花粉与8岁儿童肺功能降低有关。花粉暴露与FEV1和FVC降低有关，但FEV1/FVC比值不受影响。
结论：空气中的柏树、木麻黄、松树花粉在某些地区可能不利于儿童肺功能。
延伸阅读
Clinical & Experimental Allergy
[IF:5.158]
Tree pollen exposure is associated with reduced lung function in childrenDOI: 10.1111/cea.13711
Abstract:
Background: Allergic disease is a recognized global epidemic and a significant cause of ill health and poor quality of life. The prevalence of pollen allergy is high throughout the world, and pollen exposure itself plays a role in emergency department presentations and hospitalizations for asthma. Lung function and airway inflammation are important measures of asthma activity and control.
Methods: A cohort of high-risk children living in Sydney, Australia had spirometry and fractional exhaled nitric oxide (FeNO) measured at 8 and 14 years of age. Ambient pollen concentration on the day of lung function measurement and up to three days prior was used as the exposure measure. Residential greenness was derived from satellite imagery. We modelled the association between six pollen types and lung function and FeNO. We also assessed modifying effects of residential greenness.
Results: Casuarina, cypress and Pinus pollen in the air the day before measurement and 3 days prior respectively, were associated with reduced lung function in 8-yearolds. The pollen exposures were associated with decreases in FEV1 and FVC; however, the FEV1/FVC ratio was not affected. Effect modification by greenness was not observed due to loss of power.
Conclusions: Airborne tree pollen of cypress, Casuarina and Pinus and not grass in some regions may be detrimental to childhood lung function.
First Author:
Katrina A Lambert
Correspondence:
Bircan Erbas, School of Public Health, La Trobe University, Rm 129, Health Sciences 1, Bundoora, Vic. 3086, Australia.
All Authors:
Katrina A Lambert, Constance Katelaris, Pamela Burton, Christine Cowie, Caroline Lodge, Frances L Garden, Luke A Prendergast, Brett G Toelle, Bircan Erbas
2020-10-30 Article
创建过敏性疾病的科研、科普知识交流平台，为过敏患者提供专业诊断、治疗、预防的共享平台。
