MR分析的结果表明，青春期早熟与活动性哮喘有关（OR = 1.18； 95％CI：1.08-1.28）； 这种作用在男孩中很明显。青春期早熟显著增加了男女在12和17岁时发生哮喘的风险（危险比= 2.15； 95％CI：1.21-3.84）。 以非超重和非青春期早期儿童为参考组，我们观察到超重和青春期早熟对男女儿童的哮喘风险具有协同作用（OR = 1.08； 95％CI：1.04-1.11）。
Early pubertal maturation and risk of childhood asthma: A mendelian randomization and longitudinal study
Studies on early puberty and incident asthma have reported inconsistent results and are mainly performed in females. In this longitudinal study, we investigated the causal relationship between pubertal maturation and asthma through Mendelian randomization (MR) and explored the joint effect of overweightness and early pubertal maturation on asthma.
We used data from the Taiwan Children Health Study with longitudinal follow‐ups of 2991 children aged 11‐17 years. Six puberty‐related single‐nucleotide polymorphisms (combined into a weighted allelic score) were used to yield genetic instrumental variables for early puberty. Early pubertal maturation was defined as reaching a certain pubertal stage earlier than the median age for that stage. Incident asthma cases were calculated by excluding children with a history of asthma prior to that age.
The results of MR analysis revealed that early pubertal maturation was associated with active asthma (OR = 1.18; 95% CI: 1.08‐1.28); This effect was significant in male children. Early pubertal maturation significantly increased the risk of incident asthma outcomes at 12 and 17 years of age in both sexes (hazard ratio = 2.15; 95% CI: 1.21‐3.84). Taking non‐overweight and non–early puberty children as the reference group, we observed a synergistic effect of overweightness and early pubertal maturation on asthma risk (OR = 1.08; 95% CI: 1.04‐1.11) in children of both sexes.
Early screening and intervention for obesity are recommended to prevent future early pubertal onset and asthma occurrence.
Department of Family Medicine, Taipei Medical University Hospital, Taipei Medical University, No. 252,Wuxing St, Xinyi District, Taipei 110, Taiwan, China
Yang‐Ching Chen, Hsien‐Yu Fan, Chen Yang, Yungling L. Lee