杭州浙大迪迅生物基因工程有限公司

　　原标题：表观遗传与过敏：从基础机理到临床应用
　　在西方，过敏性疾病在上升，众所周知的过敏保护与驱动因素如微生物和饮食暴露、污染和吸烟通过改变表观遗传景观来介导它们的影响力。这里，我们回顾了过敏性疾病中参与的表观遗传学改变，总结和批判性地评估表观遗传学相关研究中经验教训。我们展示了表观遗传学在临床中的各种应用：作为诊断工具，评估免疫治疗后的耐受或在早期可能性地预测治疗的效果。另外，新的技术进步如表观基因组编辑一种脱氧核酶在将来可以对表观基因组进行目标性的修饰并提供新的治疗工具。


　　延伸阅读
Epigenomics  
Epigenetics  and allergy: from basic mechanisms to clinical applications
DOI
Abstract:
Allergic diseases are on the rise in the Western world and well-known allergy protecting and -driving factors such as microbial and dietary exposure, pollution and smoking mediate their influence through alterations of the epigenetic landscape.Here, we review key facts on the involvement of epigenetic modifications in allergic diseases and summarize and critically evaluate the lessons learned from epigenome-wide association studies. We show the potential of epigenetic changes for various clinical applications: as diagnostic tools, to assess tolerance following immunotherapy or possibly predict the success of therapy at an early time point. Furthermore, new technological advances such as epigenome editing an DNAzymes will allow targeted alterations of the epigenome in the future and provide novel therapeutic tools.
First Author:
DP Potaczek ， H Harb ， S Michel ， BA Alhamwe ， H Renz ， ...
　　创建过敏性疾病的科研、科普知识交流平台，为过敏患者提供专业诊断、治疗、预防的共享平台。