杭州浙大迪迅生物基因工程有限公司Clinical and Molecular Allergy 屋尘螨分子致敏模式从生命的第一年开始形成
发布日期：2023-03-20
原标题：屋尘螨分子致敏模式从生命的第一年开始形成，包括第 1 组、第 2 组、Der p 23、Der p 5、Der p 7 和 Der p 21
方法：数据来自使用Alex2多重过敏检测的20333名患者。使用描述性统计数据确定致敏的年龄特征，使用贝叶斯网络分析建立个体致敏的概率模式。
结果：来自乌克兰的患者最常对第1组（Der p 1，Der f 1）和第2组（Der p 2，Der f 2）的HDM过敏原组分以及Der p 23（55%）过敏。还观察到对Der p 5、Der p 7和Der p 21有相当大的敏感性。乌克兰人口对HDM过敏原组分的总体致敏性质是在出生第一年内形成的。此时，对第1组和第2组的HDM过敏原组分以及Der p 23有明显的致敏作用。对Der p 5、Der p 7和Der p 21过敏原组分的致敏意义从3~6岁开始增加。贝叶斯网络数据分析表明，对Der p 1和Der f 2的致敏起主导作用。在发展对第5组过敏原组分的敏感性时，主导作用可能来源于Der p 21。
结论：本研究所获得的结果表明了使用多组分方法确定致敏谱的重要性。由于HDM的致敏模式是在生命的第一年形成的，因此需要对AIT处方的最佳年龄进行更详细的研究。
延伸阅读
Clinical and Molecular Allergy
DOI: org/10.1186/s12948-022-00182-z
Abstract:
Background: As the process and nature of developing sensitivity to house dust mites (HDMs) remain not fully studied,our goal was to establish the pattern, nature and timeframe of house dust mite (HDM) sensitization development in patients in Ukraine as well as the period when treatment of such patients would be most effective.
Method: The data of the multiplex allergy test Alex2 was collected from 20,033 patients. To determine age specifics of sensitization, descriptive statistics were used. Bayesian Network analysis was used to build probabilistic patterns of individual sensitization.
Results: Patients from Ukraine were most often sensitized to HDM allergens of group 1 (Der p 1, Der f 1) and group 2 (Der p 2, Der f 2) as well as to Der p 23 (55%). A considerable sensitivity to Der p 5, Der p 7 and Der p 21 allergens was also observed. The overall nature of sensitization to HDM allergens among the population of Ukraine is formed within the first year of life. By this time, there is a pronounced sensitization to HDM allergens of groups 1 and 2 as well as to Der p 23. Significance of sensitization to Der p 5, Der p 7 and Der p 21 allergens grows starting from the age of 3–6.Bayesian Network data analysis indicated the leading role of sensitization to Der p 1 and Der f 2. While developing the sensitivity to group 5 allergens, the leading role may belong to Der p 21 allergen.
Conclusion: The results obtained indicate the importance of determining the sensitization profile using the multicomponent approach. A more detailed study of the optimal age for AIT prescription is required as the pattern of sensitization to HDMs is formed during the first year of life.
First Author:
Serhii Yuriev
Corresponding author:
Andrii Kurchenko
Correspondence:
Department of Clinical Immunology and Allergology, Bohomolets National Medical University, Kiev, Ukraine
——浙大迪迅译
背景：由于对尘螨（HDM）产生敏感性的过程和性质尚未得到充分研究，因此我们的目标是确定乌克兰尘螨过敏患者致敏发展的模式、性质和时间框架，以及对此类患者的治疗最有效的时期。方法：数据来自使用Alex2多重过敏检测的20333名患者。使用描述性统计数据确定致敏的年龄特征，使用贝叶斯网络分析建立个体致敏的概率模式。
结果：来自乌克兰的患者最常对第1组（Der p 1，Der f 1）和第2组（Der p 2，Der f 2）的HDM过敏原组分以及Der p 23（55%）过敏。还观察到对Der p 5、Der p 7和Der p 21有相当大的敏感性。乌克兰人口对HDM过敏原组分的总体致敏性质是在出生第一年内形成的。此时，对第1组和第2组的HDM过敏原组分以及Der p 23有明显的致敏作用。对Der p 5、Der p 7和Der p 21过敏原组分的致敏意义从3~6岁开始增加。贝叶斯网络数据分析表明，对Der p 1和Der f 2的致敏起主导作用。在发展对第5组过敏原组分的敏感性时，主导作用可能来源于Der p 21。
结论：本研究所获得的结果表明了使用多组分方法确定致敏谱的重要性。由于HDM的致敏模式是在生命的第一年形成的，因此需要对AIT处方的最佳年龄进行更详细的研究。
延伸阅读
Clinical and Molecular Allergy
[IF：1.409]
Molecular sensitization pattern to house dust mites is formed from the first years of life and includes group 1, 2, Der p 23, Der p 5, Der p 7 and Der p 21 allergensDOI: org/10.1186/s12948-022-00182-z
Abstract:
Background: As the process and nature of developing sensitivity to house dust mites (HDMs) remain not fully studied,our goal was to establish the pattern, nature and timeframe of house dust mite (HDM) sensitization development in patients in Ukraine as well as the period when treatment of such patients would be most effective.
Method: The data of the multiplex allergy test Alex2 was collected from 20,033 patients. To determine age specifics of sensitization, descriptive statistics were used. Bayesian Network analysis was used to build probabilistic patterns of individual sensitization.
Results: Patients from Ukraine were most often sensitized to HDM allergens of group 1 (Der p 1, Der f 1) and group 2 (Der p 2, Der f 2) as well as to Der p 23 (55%). A considerable sensitivity to Der p 5, Der p 7 and Der p 21 allergens was also observed. The overall nature of sensitization to HDM allergens among the population of Ukraine is formed within the first year of life. By this time, there is a pronounced sensitization to HDM allergens of groups 1 and 2 as well as to Der p 23. Significance of sensitization to Der p 5, Der p 7 and Der p 21 allergens grows starting from the age of 3–6.Bayesian Network data analysis indicated the leading role of sensitization to Der p 1 and Der f 2. While developing the sensitivity to group 5 allergens, the leading role may belong to Der p 21 allergen.
Conclusion: The results obtained indicate the importance of determining the sensitization profile using the multicomponent approach. A more detailed study of the optimal age for AIT prescription is required as the pattern of sensitization to HDMs is formed during the first year of life.
First Author:
Serhii Yuriev
Corresponding author:
Andrii Kurchenko
Correspondence:
Department of Clinical Immunology and Allergology, Bohomolets National Medical University, Kiev, Ukraine
